Mark A. Frye

Mark A. Frye, M.D., is a Consultant in the Department of Psychiatry & Psychology at Mayo Clinic. He joined the staff of Mayo Clinic in 2006 and holds the academic rank of Professor of Psychiatry, Mayo Clinic College of Medicine and Science. He is the immediate past Chair of the Department of Psychiatry & Psychology (2010-2020) and is recognized with the distinction of the Stephen and Shelley Jackson Family Professorship in Individualized Medicine.

Born and raised in Rochester Minnesota, Dr. Frye received his M.D. from the University of Minnesota and completed his psychiatric training at the Semel Institute for Neuroscience and Human Behavior at the David Geffen School of Medicine at UCLA. He subsequently completed a fellowship at the National Institute of Mental Health in Bethesda, Maryland with a research focus on the neurobiology of treatment resistant depression and bipolar disorder.

Dr. Frye’s current research centers on biomarkers of mood disorders and alcoholism, complementing his clinical expertise in mood disorders and addiction. Dr. Frye and his team established the Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder in an effort to identify the underpinning mechanisms of bipolar disorder through genomic studies. An active author, he has published more than 350 papers in peer-reviewed journals such as the New England Journal of Medicine, JAMA Psychiatry, American Journal of Psychiatry, Biological Psychiatry Neuropsychopharmaoclogy, and Journal of Clinical Psychiatry. He has received research support from NIMH, NIAAA, Mayo Foundation, Mayo Clinic Center for Individualized Medicine, Brain & Behavior Research Foundation, and industry partners.

Dr. Frye served as a scientific reviewer for the NIMH Interventions Committee for Adult Disorders (2013 2015) chairing a 2016 Special Emphasis Panel. He serves on the editorial boards of Bipolar Disorders, Journal of Affective Disorders, and International Journal of Bipolar Disorder. He also serves on the Scientific Advisory Committee to the Depression and Bipolar Support Alliance. Dr. Frye holds full master’s faculty privileges in Clinical and Translational Science at Mayo Clinic Graduate School of Biomedical Sciences. He has received numerous awards including the American College of Psychiatry Mood Disorders Research Award (2018), Gerald Klerman Senior and Young Investigator Award from the Depression and Bipolar Support Alliance (2014, 2003), the Mogens Schou Award for Education from the International Society for Bipolar Disorder 2011, Mayo Clinic Department of Psychiatry & Psychology Chief Residents’ Commitment to Education Award 2015, 2 Mayo Clinic Rome Mentorship Awards (2011, 2012) and 3 UCLA departmental medical student and resident teaching awards (1994, 2003, 2005).