Henricus G. Ruhe

Dr. Eric Ruhe is an Associate Professor at the Department of Psychiatry and Principal Investigator (PI) in Radboudumc (Nijmegen the Netherlands), also affiliated with the Donders Institute for Brain, Cognition and Behavior of Radboud University. 

Dr Ruhe has a background in clinical psychiatry, epidemiology and brain neuroimaging (molecular and functional MRI), with extensive expertise in affective disorders with specific focus on psychopharmacology and treatment of recurrent and/or treatment resistant (TRD) depressive disorders.

His ultimate aims are to apply non-invasive fMRI/molecular imaging and neuropsychological phenotyping in clinical Psychiatry to: 1. Improve diagnostic work-up of heterogeneous disorders like major depressive disorder (MDD); 2. Tailor interventions to underlying mechanistic dysfunctions; 3. Thereby improve long term recovery of MDD/TRD and 4. Disseminate successful approaches to everyday clinical care and treatment guidelines.

His research includes application of neuroimaging methods, neuropsychological assessments and smartphone-applied cognitive training and measurements in order to better understand pathophysiology behind recurrent depression and TRD, in order to both improve and eventually personalize treatments for these highly prevalent and burdensome affective disorders. Moreover, he is a principal investigator in a recently funded study to investigate how to discontinue antidepressants. As such, Dr Ruhe has a vast experience in doing randomized clinical trials in MDD populations, recruit drug-free subjects and perform long-term follow-up. In addition, he is experienced in performing systematic reviews and (network-)meta-analyses in order to obtain high-quality evidence summarizing the state of the art in psychiatry.

In his current position as PI in Radboudumc and the Donders Institute for Brain, Cognition and Behavior, he serves as a main or co-investigator on several national and EU-funded grants and he supervises several PhDs and PostDocs. He is the co-chair of the Dutch Multidisciplinary Guideline for MDD, member of the ISAD Executive Board and chair of the ECNP abstract and poster committee. He and his group (inter-)nationally collaborate to achieve the above aims in a team-science approach. In addition, also due to his clinical appointment, he has strong ties with health care providers, particularly for MDD populations in the Netherlands and abroad.

Dr Ruhe (co-) authored more than 120 peer reviewed publications, 20 chapters in books and 5 books. With his work he was given the Ramaer-medal of the Dutch Association for Psychiatry and was rewarded as a VENI-laureate.